Transport of Calcium Ions into Mitochondria

Title:Transport of Calcium Ions into Mitochondria

Volume: 17 Issue: 3

Author(s): Zhaolong Xu, Dayong Zhang, Xiaolan He, Yihong Huang and Hongbo Shao

Affiliation:

Keywords: Mitochondria, Channels, Calcium ions uptake, Uniporter.

Abstract: To uptake calcium ions of mitochondria is of significant functional connotation for cells, because calcium ions in mitochondria are involved in energy production, regulatory signals transfer, and mitochondrial permeability transition pore opening and even programmed cell death of apoptosis, further playing more roles in plant productivity and quality. Cytoplasmic calcium ions access into outer mitochondrial membrane (OMM) from voltage dependent anion-selective channel (VDAC) and were absorbed into inner mitochondrial membrane (IMM) by mitochondrial calcium uniporter (MCU), rapid mitochondrial calcium uptake (RaM) or mitochondrial ryanodine receptor (mRyR). Although both mitochondria and the mechanisms of calcium transport have been extensively studied, but there are still long-standing or even new challenges. Here we review the history and recent discoveries of the mitochondria calcium ions channel complex involved calcium assimilation, and discuss the role of calcium ions into mitochondria.

Cite this article as:

Xu Zhaolong, Zhang Dayong, He Xiaolan, Huang Yihong and Shao Hongbo, Transport of Calcium Ions into Mitochondria, Current Genomics 2016; 17 (3) . https://dx.doi.org/10.2174/1389202917666160202215748