Abstract
Regioisomerically pure 5(6)-substituted rhodamine is an outstanding molecular platform for functional probes and a very useful material for fluorescent labels. However, 5(6)-substituted rhodamine is difficult to be synthesized by general methods, which limits the application of the dye. This review highlights the progress regarding the methods for the synthesis and separation of regioisomerically pure 5(6)-substituted rhodamine, which are categorized by the four different protocols for acquiring 5(6)-substituted rhodamine. The advantages and disadvantages of each protocol are also discussed.
Keywords: Regioisomerically pure, substituted rhodamine, separation, synthesis.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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