Synthesis of Ethyl Octyl-α-Aminophosphonate Derivatives

Title:Synthesis of Ethyl Octyl-α-Aminophosphonate Derivatives

Volume: 13 Issue: 4

Author(s): Ádám Tajti, Erika Bálint and György Keglevich

Affiliation:

Keywords: Ethyl octyl phosphite, Kabachnik–Fields reaction, Ethyl octyl α-aminomethyl-phosphonates, N, N-Bis(ethyloctylphosphonoylmethyl) amines, Microwave.

Abstract: Ethyl octyl phosphite (EOP), a dialkyl phosphite with mixed alkyl groups was prepared, and utilized in the Kabachnik–Fields reaction. The condensation of EOP, paraformaldehyde and primary or secondary amines used in equimolar quantities afforded new α-aminophosphonates under microwave conditions. Methylation of the -α(alkylamino)phosphonates was also investigated. The double phospha-Mannich reaction of primary amines and two equivalents of EOP and paraformaldehyde furnished new bis(phosphonomethyl)amines.

Cite this article as:

Tajti Ádám, Bálint Erika and Keglevich György, Synthesis of Ethyl Octyl-α-Aminophosphonate Derivatives, Current Organic Synthesis 2016; 13 (4) . https://dx.doi.org/10.2174/1570179413666151218202757