Multicomponent Synthesis of Novel bis(2-amino-tetrahydro-4H-chromene-3- carbonitrile) Derivatives Linked to Arene or Heteroarene Cores

Title:Multicomponent Synthesis of Novel bis(2-amino-tetrahydro-4H-chromene-3- carbonitrile) Derivatives Linked to Arene or Heteroarene Cores

Volume: 13 Issue: 4

Author(s): Amna M. Abdella, Ahmed H. M. Elwahy and Ismail A. Abdelhamid

Affiliation:

Keywords: Bis-aldehydes, bis-arylidenemalononitriles, multicomponent reactions, Bis-4H-chromene-3-carbonitriles.

Abstract: An efficient and convenient route for synthesis of novel bis 4H-chromene-3- carbonitrile derivatives is reported. The synthetic pathway involves one pot, multi-component reaction of bis-aldehydes, malononitrile, and dimedone in the presence of a catalytic amount of piperidine. A stepwise approach for the synthesis of the target compounds was also investigated.

Cite this article as:

Abdella M. Amna, Elwahy H. M. Ahmed and A. Abdelhamid Ismail, Multicomponent Synthesis of Novel bis(2-amino-tetrahydro-4H-chromene-3- carbonitrile) Derivatives Linked to Arene or Heteroarene Cores, Current Organic Synthesis 2016; 13 (4) . https://dx.doi.org/10.2174/1570179413999151211115100