The Silicon Cell Initiative

Jacky   L.   Snoep; Hans   V.   Westerhoff

doi:10.2174/1389202043348553

Abstract

In the post genomic era and with the rapid developments in the field of Systems Biology there is an increased demand for ‘virtual cells’. Here a number of initiatives towards such cells are discussed with an emphasis on how they differ in aims and functionalities. Then one of the initiatives is described in much more detail. This ‘silicon cell’ initiative aims at producing computer replica of living organisms, with an initial focus on individual cells and pathways therein. Once journal-refereed, the replica are put onto a dedicated website, such that they can be interrogated by the worldwide scientific community. The replicas enable experimentation in silico, which may advance drug design, biotechnology and teaching. A major challenge will be the quality control and improvement, and the coupling of the replica of parts of living cells into replica of larger parts.

Keywords: Silicon Cell, genomic, biotechnology

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Current Genomics

Title: The Silicon Cell Initiative

Volume: 5 Issue: 8

Author(s): Jacky L. Snoep and Hans V. Westerhoff

Affiliation:

Keywords: Silicon Cell, genomic, biotechnology

Abstract: In the post genomic era and with the rapid developments in the field of Systems Biology there is an increased demand for ‘virtual cells’. Here a number of initiatives towards such cells are discussed with an emphasis on how they differ in aims and functionalities. Then one of the initiatives is described in much more detail. This ‘silicon cell’ initiative aims at producing computer replica of living organisms, with an initial focus on individual cells and pathways therein. Once journal-refereed, the replica are put onto a dedicated website, such that they can be interrogated by the worldwide scientific community. The replicas enable experimentation in silico, which may advance drug design, biotechnology and teaching. A major challenge will be the quality control and improvement, and the coupling of the replica of parts of living cells into replica of larger parts.

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Cite this article as:

Snoep L. Jacky and Westerhoff V. Hans, The Silicon Cell Initiative, Current Genomics 2004; 5 (8) . https://dx.doi.org/10.2174/1389202043348553

DOI https://dx.doi.org/10.2174/1389202043348553	Print ISSN 1389-2029
Publisher Name Bentham Science Publisher	Online ISSN 1875-5488

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