Hepato and Cardiotoxicity of Chemotherapeutic Treatment Evaluated by Means of Small Animal Imaging

Title:Hepato and Cardiotoxicity of Chemotherapeutic Treatment Evaluated by Means of Small Animal Imaging

Volume: 17 Issue: 3

Author(s): Fiorella Carla Tesan, Mariano Gaston Portillo, Diego Martinel-Lamas, Vanina Araceli Medina, Maria Jimena Salgueiro and Marcela Beatriz Zubillaga

Affiliation:

Keywords: Doxorubicin, cardiotoxicity, hepatotoxicity, small animal imaging, ^99mTc-phytate, ^99mTc-disida, ^99mTc-sestamibi.

Abstract: Background: Chemotherapy is one of the most common approaches for cancer treatment. Particularly Doxorubicin has been proven to be effective in the treatment of many soft and solid tumors for locally advanced and metastatic cancer. It is not easy to clinically evaluate the chemotoxic or chemoprotective effect of some drugs, even more when there is a subclinical toxicity.

Objective: To determine the usefulness of the hepatobiliary, colloid and cardiac scintigraphies, employing^99mTcdisida, ^99mTc-phytate and ^99mTc-sestamibi respectively, in the evaluation of the hepato and cardiotoxicity of two chemotherapeutic treatments assessed in rats.

Method: Two groups were submitted to doxorubicin (DOX) treatment and one was co-administered with histamine (DOX+HIS). Static ^99mTc-phytate and ^99mTc-sestamibi scintigraphies as well as a dynamic ^99mTc-disida study were performed in a small field of view gamma camera at: 0 weeks (control), 1 week and 2 weeks of treatment. Imagenological parameters were calculated: Liver/Bone Marrow ratio (L/BM), Heart/Background ratio (H/B) and time to the maximum (Tmax) for 99mTc-phytate, 99mTc-sestamibi and 99mTc-disida extraction, respectively.

Results: Control (L/BM= 98±3; H/B=2.3±0.4; Tmax=8±3), DOX (L/BM: 85±3, 80±3; H/B, 3.5±0.5, 3.3±0.5 and Tmax 6±1, 4±1) for 1 and 2 weeks respectively and DOX+HIS (L/BM: 99±0.3, 98±1; H/B 2.9±0.5, 2.9±0.5 and Tmax, 8±2, 9±2) for 1 and 2 weeks, respectively. Histological analysis showed cardio and hepatotoxicity induced by doxorubicin.

Conclusion: Imagenological parameters showed differences among treated and control groups and between both chemotherapy treatments. Thus, these radiopharmaceutical functional approaches were able to reflect heart and liver toxicity produced by doxorubicin.

Cite this article as:

Tesan Carla Fiorella, Portillo Gaston Mariano, Martinel-Lamas Diego, Medina Araceli Vanina, Salgueiro Jimena Maria and Zubillaga Beatriz Marcela, Hepato and Cardiotoxicity of Chemotherapeutic Treatment Evaluated by Means of Small Animal Imaging, Anti-Cancer Agents in Medicinal Chemistry 2017; 17 (3) . https://dx.doi.org/10.2174/1871520616666151110130619

DOI https://dx.doi.org/10.2174/1871520616666151110130619	Print ISSN 1871-5206
Publisher Name Bentham Science Publisher	Online ISSN 1875-5992