Interaction studies of Withania somnifera’s key metabolite Withaferin A with different receptors associated with cardiovascular disease

Title:Interaction studies of Withania somnifera’s key metabolite Withaferin A with different receptors associated with cardiovascular disease

Volume: 11 Issue: 3

Author(s): Rekha Ravindran, Nitika Sharma, Sujata Roy, Ashoke R. Thakur, Subhadra Ganesh, Sriram Kumar, Jamuna Devi and Johanna Rajkumar

Affiliation:

Keywords: Docking, Ashwagandha, herbal, beta receptor.

Abstract: Withania somnifera commonly known as Ashwagandha in India is used in many herbal formulations to treat various cardiovascular diseases. The key metabolite of this plant, Withaferin A was analyzed for its molecular mechanism through docking studies on different targets of cardiovascular disease. Six receptor proteins associated with cardiovascular disease were selected and interaction studies were performed with Withaferin A using AutoDock Vina. CORINA was used to model the small molecules and HBAT to compute the hydrogen bonding. Among the six targets, β1- adrenergic receptors, HMG-CoA and Angiotensinogen-converting enzyme showed significant interaction with Withaferin A. Pharmacophore modeling was done using PharmaGist to understand the pharmacophoric potential of Withaferin A. Clustering of Withaferin A with different existing drug molecules for cardiovascular disease was performed with ChemMine based on structural similarity and physicochemical properties. The ability of natural active component, Withaferin A to interact with different receptors associated with cardiovascular disease was elucidated with various modeling techniques. These studies conclusively revealed Withaferin A as a potent lead compound against multiple targets associated with cardiovascular disease.

Cite this article as:

Ravindran Rekha, Sharma Nitika, Roy Sujata, Thakur R. Ashoke, Ganesh Subhadra, Kumar Sriram, Devi Jamuna and Rajkumar Johanna, Interaction studies of Withania somnifera’s key metabolite Withaferin A with different receptors associated with cardiovascular disease, Current Computer-Aided Drug Design 2015; 11 (3) . https://dx.doi.org/10.2174/1573409912666151106115848