细胞吞噬-细胞死亡的吞噬作用,在生理学、宿主防御和病理中扮演着中心角色

Title:Phagoptosis - Cell Death By Phagocytosis - Plays Central Roles in Physiology, Host Defense and Pathology

Volume: 15 Issue: 9

Author(s): G. C. Brown, A. Vilalta and M. Fricker

Affiliation:

关键词: Phagocytosis

摘要: Cell death by phagocytosis – termed ‘phagoptosis’ for short – is a form of cell death caused by the cell being phagocytosed i.e. recognised, engulfed and digested by another cell. Phagocytes eat cells that: i) expose ‘eat-me’ signals, ii) lose ‘don’t-eat-me’ signals, and/or iii) bind opsonins. Live cells may express such signals as a result of cell stress, damage, activation or senescence, which can result in phagoptosis. Phagoptosis may be the most abundant form of cell death physiologically as it mediates erythrocyte turnover. It also regulates: reproduction by phagocytosis of sperm, development by removal stem cells and excess cells, and immunity by removal of activated neutrophils and T cells. Phagoptosis mediates the recognition of non-self and host defence against pathogens and cancer cells. However, in inflammatory conditions, excessive phagoptosis may kill our cells, leading to conditions such as hemophagy and neuronal loss.

Cite this article as:

G. C. Brown, A. Vilalta and M. Fricker , Phagoptosis - Cell Death By Phagocytosis - Plays Central Roles in Physiology, Host Defense and Pathology, Current Molecular Medicine 2015; 15 (9) . https://dx.doi.org/10.2174/156652401509151105130628