Abstract
In this review, recent application of trifluoroacetaldehyde ethyl hemiacetal (TFAE) in the preparation of α-trifluoromethyl alcohols and α-trifluoromethyl amines, especially by the direct regioselective and stereoselective substitution of TFAE and its derivatives like imines with various aromatic and heteroaromatic compounds, is reviewed. Moreover, some useful methods for preparing important potentially bioactive fluorinated compounds, such as o- and p-substituted fluoroalkylphenols and β-trifluoromethyl amino acids, are also introduced.
Keywords: trifluoroacetaldehyde, reagent, nucleophiles, reaction, benzenes, phenols, amines
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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