An Efficient and Improved Process for the Scale-up Preparation of cis- Cyclopropanediamine Dihydrochloride

Title:An Efficient and Improved Process for the Scale-up Preparation of cis- Cyclopropanediamine Dihydrochloride

Volume: 12 Issue: 10

Author(s): Fan Wang, Xiao-Ying Xu, Fei-Ying Wang, Lin Peng, Yong Zhang, Liang-Liang Wang and Li-Xin Wang

Affiliation:

Keywords: cis-cyclopropanediamine dihydrochloride, Curtius rearrangement, scale-up preparation.

Abstract: An effective and improved process for the preparation of cis-cyclopro panediamine dihydrochloride was developed in a 100 g scale. The key step in the process is the preparation of ciscyclopropane- 1, 2-dicarboxylic acid from a mixture of cis- and trans- isomers by the formation of cyclic acidic anhydride. The whole process and all of the procedures are economical, industrially reliable and easily scaled up.

Cite this article as:

Wang Fan, Xu Xiao-Ying, Wang Fei-Ying, Peng Lin, Zhang Yong, Wang Liang-Liang and Wang Li-Xin, An Efficient and Improved Process for the Scale-up Preparation of cis- Cyclopropanediamine Dihydrochloride, Letters in Organic Chemistry 2015; 12 (10) . https://dx.doi.org/10.2174/1570178612666150907204813