Functional Neurochemistry of Alzheimers Disease

Title: Functional Neurochemistry of Alzheimers Disease

Volume: 10 Issue: 3

Author(s): Wieland Gsell, Gerd Jungkunz and Peter Riederer

Affiliation:

Keywords: Neurochemistry, acetylcholineesterase, serotonin, dopamine, glutamate, GABA, noradrenaline

Abstract: A review of neurochemical research on classical neurotransmitters, i.e. acetylcholine, serotonin, noradrenaline, dopamine, glutamate, and GABA in Alzheimers disease is presented. Findings are linked to the information processing system of the human brain to establish a more functional neurochemistry. On this basis, different pharmacotherapeutic strategies are discussed. Our conclusion is that current symptomatic therapy of Alzheimers disease is insufficient. Besides therapy with acetylcholineesterase inhibitors, comedication to act on imbalances between serotonin and noradrenaline on the one site, and dopamine, glutamate and GABA on the other site should should be considered.

Cite this article as:

Gsell Wieland, Jungkunz Gerd and Riederer Peter, Functional Neurochemistry of Alzheimers Disease, Current Pharmaceutical Design 2004; 10 (3) . https://dx.doi.org/10.2174/1381612043386473