Title:Endothelial Cell Senescence and Inflammaging: MicroRNAs as Biomarkers and Innovative Therapeutic Tools
Volume: 17
Issue: 4
Author(s): Francesco Prattichizzo, Massimiliano Bonafe, Artan Ceka, Angelica Giuliani, Maria Rita Rippo and Massimo Re, Roberto Antonicelli, Antonio Domenico Procopio and Fabiola Olivieri
Affiliation:
关键词:
癌症，细胞衰老，内皮细胞，内皮细胞功能减退，炎症衰老，微小RNA，miR-126-3p，NFkB，衰老，超声波分解化合物，T2DM.
摘要: Aging is accompanied by a progressive decline of endothelial function and a progressive
drift toward a systemic pro-inflammatory status that has been designated “inflammaging”. Both phenomena
are accelerated and exacerbated in patients with the most common age-related diseases
(ARDs), including cancer. The finding that chronic cell stress activates a pro-inflammatory program
leading to acquisition of the senescence-associated secretory phenotype (SASP) and to the propagation of senescence to
surrounding cells through the secretome, suggests that cell senescence may have a role in both processes. Here we: i) describe
the role of cell senescence in endothelial dysfunction, ii) emphasize the contribution of the endothelial cell SASP to
inflammaging, and iii) suggest that selective removal of senescent endothelial cells may not only hinder such harmful
processes, but also reduce the risk of developing ARDs and their complications. Although in vivo detection and targeting
of senescent endothelial cells are still being investigated, it is likely that therapeutic strategies based on antioxidant and
anti-inflammatory compounds would involve generalized anti-aging effects also benefiting endothelial cells. MicroRNA
(miRNAs) - single-stranded, non-coding RNAs expressed by all living cells and involved in the epigenetic modulation of
all transcriptional programs - may constitute an innovative, valuable tool to detect and target senescent endothelial cells
and to devise treatments that can slow down the pro-inflammatory program activated in senescent endothelial cells.
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