Abstract
Secondary metabolites containing oxazole, oxazoline and isoxazoline ring skeletons are widely distributed in both marine and terrestrial organisms. They possess significant biological activities such as anti-tumor, antibacterial, anti-viral, anti-malarial and immunosuppressive. The complexity in the molecular structures coupled with their wide biological properties, has attracted the attention of many synthetic and natural product chemists. The introduction of multifunctional substituents and the construction of stereo-centers were considered as major challenges and obstacles in developing synthetic protocol for these classes of compounds. Few review articles on the total synthesis of oxazole contaning marine natural products namely bengazoles, phorboxazole, pseudopteroxazoles, hennoxazole and cyclopeptide have been reported till date. However, these reviews omitted the discussion on isolation and biological activities. In this review, we present the brief account on isolation, relevant biological activities and a recent development on the total synthesis of marine natural products containing oxazole, oxazoline and isoxazoline ring skeletons reported till 2014.
Keywords: Oxazole, oxazoline, isoxazoline, marine natural products, total synthesis.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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