The Role of Topiramate in the Management of Cocaine Addiction: a Possible Therapeutic Option

Title:The Role of Topiramate in the Management of Cocaine Addiction: a Possible Therapeutic Option

Volume: 13 Issue: 6

Author(s): Antonio Siniscalchi, Antonello Bonci, Nicola Biagio Mercuri, Domenico Pirritano, Aida Squillace, Giovambattista De Sarro and Luca Gallelli

Affiliation:

Keywords: Cocaine dependence, gamma-aminobutyric acid neurotransmission, glutamatergic neurotransmission, topiramate.

Abstract: Topiramate (TPM) is an antiepileptic drug able to play a role in both neurological and psychiatric disorders. TPM facilitates gamma-aminobutyric acid (GABA) transmission and inhibits glutamatergic transmission (i.e. AMPA/kainate receptors).

Several studies reported that the modulation of GABAergic and glutamatergic synaptic transmission may reduce cocaine reinforcement. Therefore, TPM could be used in the management of cocaine dependence.

Cite this article as:

Siniscalchi Antonio, Bonci Antonello, Biagio Mercuri Nicola, Pirritano Domenico, Squillace Aida, De Sarro Giovambattista and Gallelli Luca, The Role of Topiramate in the Management of Cocaine Addiction: a Possible Therapeutic Option, Current Neuropharmacology 2015; 13 (6) . https://dx.doi.org/10.2174/1570159X13666150729222643