摘要
癌症的发展主要是由于细胞死亡的解除管制癌细胞抗凋亡通过Bcl-2家族抗凋亡蛋白的表达增加。Mcl-1是一种抗凋亡蛋白，其主要负责癌细胞阻力，因为它在大多数癌细胞类型中过度表达。许多研究项目的目标是通过靶向抗凋亡蛋白天然药理支架，以抑制其在癌症发展的效果，恢复癌细胞死亡。本文主要介绍了Bcl-2蛋白的天然化合物抑制剂，重点在MCL-1。
关键词: 细胞凋亡，癌症，Mcl-1，天然化合物
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