Abstract
The first part of the review brings forth the detailed synthesis of the known camphor-derived organocatalysts. Most synthetic steps are operationally simple, enabling the preparation of the corresponding catalysts on a larger scale. Frequently, the bicyclic framework of camphor is connected with a proline-derivative through a suitable spacer, which enables the preparation of a library of organocatalysts needed for the fine-tuning of a selected stereoselective transformation. The second part of the review focuses on the application of camphor-derived organocatalysts in various fields of asymmetric organocatalysis. Catalytic reactions are often conducted under mild reaction conditions giving the corresponding products in good to excellent stereoselectivities.
Keywords: Camphor, ketopinic acid, camphorsulfonic acid, proline, pyrrolidine, asymmetric organocatalysis, N-heterocyclic carbene.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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