Microwave Assisted One-Pot Synthesis of Novel Trifluoromethyl Coumarin Thiosemicarbazones and their Antifungal Activities

Title:Microwave Assisted One-Pot Synthesis of Novel Trifluoromethyl Coumarin Thiosemicarbazones and their Antifungal Activities

Volume: 3 Issue: 1

Author(s): Guoyu Yang, Cuilian Xu, Mingqin Zhao, Caixia Wang, Sufang Fan, Puhui Xie and Xin Li

Affiliation:

Keywords: Antifungal activity, microwave synthesis, one-pot synthesis, solvent-free, trifluoromethyl coumarin thiosemicarbazones.

Abstract: Some new trifluoromethyl coumarin thiosemicarbazones 3a-3m were synthesized by condensation reaction of thiosemicarbazides and 3-trifluoroacetyl coumarins which was from recyclization of ethyl 2-hydroxy-2-(trifluoromethyl)-2H-chromene-3-carboxylates under microwave assisted and solvent-free conditions. The structure of the synthesized compounds were characterized by IR, ¹H NMR, ¹³C NMR, HRMS and X-ray, and their antifungal activity was evaluated. Most of them exhibited potent antifungal activity by comparison with the standard drugs.

Cite this article as:

Yang Guoyu, Xu Cuilian, Zhao Mingqin, Wang Caixia, Fan Sufang, Xie Puhui and Li Xin, Microwave Assisted One-Pot Synthesis of Novel Trifluoromethyl Coumarin Thiosemicarbazones and their Antifungal Activities, Current Microwave Chemistry 2016; 3 (1) . https://dx.doi.org/10.2174/2213335602666150702161715