Abstract
Corey-Fuchs olefination is a two-step reaction, involving the reaction of an aldehyde and tetrabromomethane (CBr4) in the presence of the triphenylphosphine (Ph3P) to synthesize 1,1-dibromoolefins. In the second step, the conversion of the dibromoolefins to alkynes occurred in the presence of n-BuLi as the base. This transformation was first discovered by E. J. Corey and P. L. Fuchs in 1972. Due to the importance of terminal alkynes in the synthetic organic chemistry, the Corey-Fuchs reaction has found many applications in organic transformations; particularly in the total synthesis of several biologically active natural products, often as starting materials.
Keywords: Corey-Fuchs, Olefination, 1, 1-Dibromoolefins, Total synthesis, Organic synthesis, Terminal alkynes, Triphenylphosphine.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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