广谱的AmpC头孢菌素的结构和功能

Title:Structural and Functional Aspects of Extended-Spectrum AmpC Cephalosporinases

Volume: 17 Issue: 9

Author(s): Rachel A. Powers

Affiliation:

关键词: Β-内酰胺酶；头孢菌素；广谱；构效；X射线晶体结构

摘要: β-lactam antibiotics have revolutionized modern medicine, but resistance to these drugs is a major public health crisis. Traditionally, class C β-lactamases were referred to as cephalosporinases due to their substrate preference for this particular class of β-lactams. However, the emergence of AmpC enzymes with extended-spectrum activity (extended-spectrum cephalosporinases or ESACs) is particularly worrisome, especially given that most clinical β-lactamase inhibitors are ineffective against these enzymes. This review summarizes structures of several extended spectrum class C β-lactamases and analyzes the structure-function relationship observed among them.

Cite this article as:

Rachel A. Powers , Structural and Functional Aspects of Extended-Spectrum AmpC Cephalosporinases, Current Drug Targets 2016; 17 (9) . https://dx.doi.org/10.2174/1573399811666150615144707