A Concise Stereoselective Total Synthesis of (–) - Cephalosporolide D

Yapuri      Umanadh; Gudaparthi      Omprakash; Narahari      Srinivasareddy

doi:10.2174/157017861206150604154329

Abstract

A concise stereoselective total synthesis of (-) - Cephalosporolide D, an eight membered lactone ring has been derived from low cost and easily available starting material (±)-propylene epoxide. The key steps involved in this concise synthesis are Sharpless kinetic resolution, Grignard reaction and Yamaguchi macrolactonisation.

Keywords: (±)-propylene epoxide, sharpless kinetic resolution, yamaguchi macrolactonisation, stereoselective synthesis and (-) - cephalosporolide D.

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Letters in Organic Chemistry

Title:A Concise Stereoselective Total Synthesis of (–) - Cephalosporolide D

Volume: 12 Issue: 6

Author(s): Yapuri Umanadh, Gudaparthi Omprakash and Narahari Srinivasareddy

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Keywords: (±)-propylene epoxide, sharpless kinetic resolution, yamaguchi macrolactonisation, stereoselective synthesis and (-) - cephalosporolide D.

Abstract: A concise stereoselective total synthesis of (-) - Cephalosporolide D, an eight membered lactone ring has been derived from low cost and easily available starting material (±)-propylene epoxide. The key steps involved in this concise synthesis are Sharpless kinetic resolution, Grignard reaction and Yamaguchi macrolactonisation.

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Umanadh Yapuri, Omprakash Gudaparthi and Srinivasareddy Narahari, A Concise Stereoselective Total Synthesis of (–) - Cephalosporolide D, Letters in Organic Chemistry 2015; 12 (6) . https://dx.doi.org/10.2174/157017861206150604154329

DOI https://dx.doi.org/10.2174/157017861206150604154329	Print ISSN 1570-1786
Publisher Name Bentham Science Publisher	Online ISSN 1875-6255