Recent Developments of New DNA Origami Nanostructures for Drug Delivery

Title:Recent Developments of New DNA Origami Nanostructures for Drug Delivery

Volume: 21 Issue: 22

Author(s): Juan Yan, Chongya Hu, Xunwei Liu, Jian Zhong, Gang Sun and Dannong He

Affiliation:

Keywords: Drug delivery, DNA origami nanostructures, scaffolds, staple strands, structural DNA nanotechnology.

Abstract: DNA origami technique was first introduced in 2006 by Rothemund, it has gained widespread research interest and led to explosive achievements, in which long single-stranded DNA (ssDNA) is folded into a designed nanostructure, in either two dimensions (2D) or three dimensions (3D), with the aid of many shorter staple strands. A series of methods for new design principles for DNA origami nanostructures have already been proposed, ranging from the preparation of scaffold to the folding mechanisms. After that, novel strategies in functionalizing DNA origami nanostructures and their practical applications are gradually becoming research hotspots. This review focuses on the development in the new scaffold design approaches, folding conditions, various nano objects functionalized on DNA origami nanostructures, and their applications as drug carriers in the recent five years. We anticipate more exploratory and extendible work developed based on the summary of progress obtained previously.

Cite this article as:

Yan Juan, Hu Chongya, Liu Xunwei, Zhong Jian, Sun Gang and He Dannong, Recent Developments of New DNA Origami Nanostructures for Drug Delivery, Current Pharmaceutical Design 2015; 21 (22) . https://dx.doi.org/10.2174/1381612821666150531165551