Nanoparticle-Based Combination Therapy for Cancer Treatment

Title:Nanoparticle-Based Combination Therapy for Cancer Treatment

Volume: 21 Issue: 22

Author(s): Ji Young Yhee, Sejin Son, Hyukjin Lee and Kwangmeyung Kim

Affiliation:

Keywords: Cancer, combination therapy, nanoparticle, targeted drug delivery.

Abstract: In recent years, combination of different types of therapies using nanoparticles has emerged as an advanced strategy for cancer treatment. Most of all, combination of chemotherapeutic drug and siRNA in nanoformulation has shown a great potential, because siRNA-mediated specific gene silencing can compensate for the incomplete anti-cancer actions of chemotherapy. In this article, nanoparticle-based combination therapy for cancer treatment is introduced to be focused on the therapeutic chemical and siRNA combination. It is classified into 3 groups: 1) general chemotherapy combined with siRNA carrying nanoparticle, 2) co-delivery of chemical and siRNA therapeutics within a single nanoparticle, and 3) Use of multiple nanoparticles for chemical and siRNA therapeutics. The purpose of the combination and the mechanisms of anti-cancer action was described according to the categories. Examples of some recent developments of nanotechnology-based chemo- and siRNA- therapeutics combination therapy are summarized for better understanding of its practical application.

Cite this article as:

Yhee Young Ji, Son Sejin, Lee Hyukjin and Kim Kwangmeyung, Nanoparticle-Based Combination Therapy for Cancer Treatment, Current Pharmaceutical Design 2015; 21 (22) . https://dx.doi.org/10.2174/1381612821666150531165059