Abstract
The studies on the reaction of arynes with the π-bond are limited, although synthetic chemistry using aryne has attracted substantial attention. This review highlights the insertion of arynes into the π-bond giving the formal [2+2] cycloaddition-type adducts. In this review, the synthetic organic reactions involving the [2+2]-type reactions of arynes with the carbon-carbon double bond, the carbon-heteroatom double bond and the heteroatomheteroatom double bond are summarized.
Keywords: Aryne, benzyne, insertion, [2+2] cycloaddition.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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