Synthesis of Dichlorophenyl-, Cyanophenyl- and Quinolinyl-Substituted

Title:Synthesis of Dichlorophenyl-, Cyanophenyl- and Quinolinyl-Substituted

Volume: 12 Issue: 6

Author(s): Clare E. Gutteridge, Sean M. Curtis, Joshua W. Major, Daniel A. Nin, Apurba K. Bhattacharjee, Daniel A. Nichols and Lucia Gerena

Affiliation:

Keywords: 2-Ethoxyacetamide, 2-ethoxyphenylacetamide, ethylation, phenylacetic acid.

Abstract: A series of ten new 2,3,6-substituted quinazolin-4(3H)-one derivatives (10a-j) were prepared from anthranilic acid (1) in a simple and economical path in a series of reactions and screened for their anticancer activity against pancreatic cancer cell line (PANC-1) using MTT assay. The results reveal that at concentration 100 µM/L, compounds 10b, 10f, 10g and 10h exhibited potential anticancer activity by inhibiting the growth of PANC-1 cells by >75% and remaining compounds showed moderate anticancer activity. The structural characterization of the synthesized compounds was elucidated by ¹H & ¹³C NMR, LC-MS, FT-IR and elemental analysis. As potential anti-tumor agents, these new derivatives show promise for further research.

Cite this article as:

Gutteridge E. Clare, Curtis M. Sean, Major W. Joshua, Nin A. Daniel, Bhattacharjee K. Apurba, Nichols A. Daniel and Gerena Lucia, Synthesis of Dichlorophenyl-, Cyanophenyl- and Quinolinyl-Substituted , Letters in Organic Chemistry 2015; 12 (6) . https://dx.doi.org/10.2174/1570178612666150501004856