Abstract
The difunctionalization of unsaturated carbon-carbon double bond is a powerful strategy for the construction of compounds with various functional groups. The present review aims to highlight the recent developments in the fluorination of alkenes with concomitant introduction of additional functional groups. Various methods are described for both intramolecular and intermolecular fluorofunctionalization of alkenes. These fluorofunctionalization processes should find broad applications in pharmaceutical and material industries.
Keywords: Alkene, difunctionalization, fluorine, intermolecular, intramolecular, regioselective.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Books
Advances in Organic Synthesis
The Synthetic Methods, Structures, and Properties of the Ca-C σ Bond Organocalcium Containing Compounds
Advances in Organic Synthesis
Chemistry of Bipyrazoles: Synthesis and Applications
Advances in Organic Synthesis
Advanced Nanocatalysis for Organic Synthesis and Electroanalysis
Advances in Organic Synthesis
Advances in Organic Synthesis
51
2