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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Screening for Protease Substrate by Polyvalent Phage Display

Author(s): Radislav Sedlacek and Emily Chen

Volume 8, Issue 2, 2005

Page: [197 - 203] Pages: 7

DOI: 10.2174/1386207053258541

Price: $65

Abstract

Proteases are key regulators of many physiological and pathological processes [1,2], and are recognized as important and tractable drug candidates. Consequently, knowledge of protease substrate recognition and specificity promotes identification of biologically relevant substrates, helps elucidating a

Keywords: phage display, matrix metalloproteinases, substrate profiling


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