Synthetic Peptide Arrays and Peptide Combinatorial Libraries for the Exploration of Protein-Ligand Interactions and the Design of Protein Inhibitors

Title: Synthetic Peptide Arrays and Peptide Combinatorial Libraries for the Exploration of Protein-Ligand Interactions and the Design of Protein Inhibitors

Volume: 8 Issue: 2

Author(s): Jutta Eichler

Affiliation:

Keywords: protein-ligand interactions, protein chips, two-dimensional arrays, synthetic peptide combinatorial libraries, surface plasmon resonance, infectious diseases, signal transduction kinase, phosphotransferase system

Abstract: Synthetic peptides have a long tradition as molecular tools in biomedical research and drug discovery. The introduction of high-throughput synthesis and screening technologies for synthetic peptides, such as arrays and combinatorial libraries, enabled the large-scale and detailed exploration of protein-ligand interactions, as well as the discovery of novel biologically active peptides. This review summarizes currently available synthetic peptide array and library technologies, in particular mixture-based peptide libraries, which are illustrated by numerous applications in various fields of biomedical research.

Cite this article as:

Eichler Jutta, Synthetic Peptide Arrays and Peptide Combinatorial Libraries for the Exploration of Protein-Ligand Interactions and the Design of Protein Inhibitors, Combinatorial Chemistry & High Throughput Screening 2005; 8 (2) . https://dx.doi.org/10.2174/1386207053258497

DOI https://dx.doi.org/10.2174/1386207053258497	Print ISSN 1386-2073
Publisher Name Bentham Science Publisher	Online ISSN 1875-5402