MicroRNAs Contribute to Hepatocellular Carcinoma

Title:MicroRNAs Contribute to Hepatocellular Carcinoma

Volume: 15 Issue: 6

Author(s): Yang Song, Fei Wang, Qi Huang, Yan Cao, Yingying Zhao and Changqing Yang

Affiliation:

Keywords: Apoptosis, hepatocellular carcinoma, meta, MicroRNA, proliferation.

Abstract: Hepatocellular carcinoma is a leading unnatural death worldwide, and it causes second most common cancer related death. Hepatocellular carcinoma development is distinct from other types of cancer, which is usually based on hepatic cirrhosis resulted from various etiologies including viral hepatitis, non-alcoholic liver diseases and alcohol abuse. MicroRNAs (miRNAs) are a group of small, non-coding sequences with approximate 20~ bp in length, which post-transcriptionally regulates target genes to control multiple biological activities. Recent studies have indicated that miRNAs contribute to hepatocellular carcinoma, indicating that targeting miRNAs might be a novel therapeutic strategy for the management of hepatocellular carcinoma. In this review, we summarized recent advances in the role of miRNAs in hepatocellular carcinoma, and also discussed the potential therapeutic and prognostic values of miRNAs in hepatocellular carcinoma.

Cite this article as:

Song Yang, Wang Fei, Huang Qi, Cao Yan, Zhao Yingying and Yang Changqing, MicroRNAs Contribute to Hepatocellular Carcinoma, Mini-Reviews in Medicinal Chemistry 2015; 15 (6) . https://dx.doi.org/10.2174/1389557515666150324125353