Candidiasis: A Fungal Infection- Current Challenges and Progress in Prevention and Treatment

Title:Candidiasis: A Fungal Infection- Current Challenges and Progress in Prevention and Treatment

Volume: 15 Issue: 1

Author(s): Umme Hani, Hosakote G. Shivakumar, Rudra Vaghela, Riyaz Ali M. Osmani and Atul Shrivastava

Affiliation:

Keywords: Antifungal agents, C. albicans, candidiasis, host defense, probiotics, vaccine.

Abstract: Despite therapeutic advances candidiasis remains a common fungal infection most frequently caused by C. albicans and may occur as vulvovaginal candidiasis or thrush, a mucocutaneous candidiasis. Candidiasis frequently occurs in newborns, in immune-deficient people like AIDS patients, and in people being treated with broad spectrum antibiotics. It is mainly due to C. albicans while other species such as C. tropicalis, C. glabrata, C. parapsilosis and C. krusei are increasingly isolated. OTC antifungal dosage forms such as creams and gels can be used for effective treatment of local candidiasis. Whereas, for preventing spread of the disease to deeper vital organs, candidiasis antifungal chemotherapy is preferred. Use of probiotics and development of novel vaccines is an advanced approach for the prevention of candidiasis. Present review summarizes the diagnosis, current status and challenges in the treatment and prevention of candidiasis with prime focus on host defense against candidiasis, advancements in diagnosis, probiotics role and recent progress in the development of vaccines against candidiasis.

Cite this article as:

Hani Umme, G. Shivakumar Hosakote, Vaghela Rudra, Ali M. Osmani Riyaz and Shrivastava Atul, Candidiasis: A Fungal Infection- Current Challenges and Progress in Prevention and Treatment, Infectious Disorders - Drug Targets 2015; 15 (1) . https://dx.doi.org/10.2174/1871526515666150320162036