Identification and Synthesis of Major Impurities Formed During the Synthesis of Trifloxystrobin and Kresoxim-methyl Fungicides

Title:Identification and Synthesis of Major Impurities Formed During the Synthesis of Trifloxystrobin and Kresoxim-methyl Fungicides

Volume: 12 Issue: 5

Author(s): Pasumpon Kamaraj, Nakita Antao, Apoorva Singh, Vijay Satam, Subhash Kadam, Venkatesh M. Prabhu, Rama Mohan Hindupur and Hari N. Pati

Affiliation:

Keywords: Fungicide, impurities, Kresoxim-methyl, pharmacophore, strobilurins, Trifloxystrobin.

Abstract: During process development of Trifloxystrobin and Kresoxim-methyl fungicides, two impurities were identified. These impurities were isolated and characterized using LCMS, IR, ¹H NMR, ¹³C NMR and elemental analysis. Structures of the impurities were further unambiguously confirmed by their independent synthesis. Structure of both impurities revealed that they possess methyl (E)-methoxyiminoacetate pharmacophore, responsible for antifungal activities of strobilurins, in combination with arylmethyl (E)-methoxyiminoacetate framework.

Cite this article as:

Kamaraj Pasumpon, Antao Nakita, Singh Apoorva, Satam Vijay, Kadam Subhash, Prabhu M. Venkatesh, Hindupur Mohan Rama and Pati N. Hari, Identification and Synthesis of Major Impurities Formed During the Synthesis of Trifloxystrobin and Kresoxim-methyl Fungicides, Letters in Organic Chemistry 2015; 12 (5) . https://dx.doi.org/10.2174/1570178612666150318002831