Chemistry and bifunctional chelating agents for binding ¹⁷⁷Lu

Title:Chemistry and bifunctional chelating agents for binding ¹⁷⁷Lu

Volume: 8 Issue: 2

Author(s): Józef L. Parus, Dariusz Pawlak, Renata Mikolajczak and Adriano Duatti

Affiliation:

Keywords: Bifunctional chelators, chemistry of lutetium, DOTA, DTPA, lanthanides, Lutetium, lutetium-177 radiopharmaceuticals, lutetium-177, NOTA.

Abstract: A short overview of fundamental chemistry of lutetium and of structural characteristics of lutetium coordination complexes, as relevant for understanding the properties of lutetium-177 radiopharmaceuticals, is presented. This includes basic concepts on lutetium electronic structure, lanthanide contraction, coordination geometries, behavior in aqueous solution and thermodynamic stability. An illustration of the structure and binding properties of the most important chelating agents for the Lu³⁺ ion in aqueous solution is also reported with specific focus on coordination complexes formed with linear and macrocyclic polydentate amino-carboxylate donor ligands.

Cite this article as:

Parus L. Józef, Pawlak Dariusz, Mikolajczak Renata and Duatti Adriano, Chemistry and bifunctional chelating agents for binding ¹⁷⁷Lu, Current Radiopharmaceuticals 2015; 8 (2) . https://dx.doi.org/10.2174/1874471008666150312160440