Abstract
Reductive amination is considered as the most popular and established approaches which provide rapid access to different types of amines, important intermediates for the production of natural products and organic compounds, and also synthesis of essential precursors needed for drug development in chemical and biological systems. The current review discusses the progress of reductive amination catalysis from 2008 to the latest one. Also, efficacy of different reagents including organocatalysts, asymmetric and symmetric complexes of Ir, Rh, and Ru, boron, silicon reagents for enantio-, chemo-, and diastereoselective reactions is illustrated under various reaction conditions with a focus on the yield of the obtained products. Biocatalytic reductive amination for the synthesis of chiral amines and also utility of this reaction for the development of bioactive molecules are also briefly described.
Keywords: Boron reagents, organocatalyst, reductive amination, silicon reagent, transfer hydrogenation, transition metal.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Books
Advances in Organic Synthesis
The Synthetic Methods, Structures, and Properties of the Ca-C σ Bond Organocalcium Containing Compounds
Advances in Organic Synthesis
Chemistry of Bipyrazoles: Synthesis and Applications
Advances in Organic Synthesis
Advanced Nanocatalysis for Organic Synthesis and Electroanalysis
Advances in Organic Synthesis
Advances in Organic Synthesis
99
3