摘要
抗菌肽 (AMPs) 是由包括从真核生物至两栖动物、昆虫、植物等所有生命体在内的多种有机体的先天免疫系统产生的氨基酸小分子的异质群体。许多AMPs是从自然资源中分离得到,许多其他AMPs被从头设计和合成产生。AMPs在微摩尔范围内有抗菌活性,且与传统抗生素相比可以快速杀菌。它们主要通过静电吸引负电荷细菌细胞然后破坏细胞膜而起作用,但其抗菌活性也可能与干扰代谢过程或不同细胞质靶标有关。AMPs是一个独特的、难以置信的化合物群体,可以直接单独使用或与现有抗生素结合使用。
关键词: 双性的α-螺旋肽,抗菌肽,构象柔性,耐多药菌。
Current Medicinal Chemistry
Title:Antimicrobial Peptides as an Opportunity Against Bacterial Diseases
Volume: 22 Issue: 14
Author(s): Stefania Galdiero, Annarita Falanga, Rita Berisio, Paolo Grieco, Giancarlo Morelli and Massimiliano Galdiero
Affiliation:
关键词: 双性的α-螺旋肽,抗菌肽,构象柔性,耐多药菌。
摘要: Antimicrobial peptides (AMPs) are an heterogeneous group of small amino acidic molecules produced by the innate immune system of a variety of organisms encompassing all orders of life from eukaryotes to amphibians, insects and plants. Numerous AMPs have been isolated from natural sources and many others have been de novo designed and synthetically produced. AMPs have antimicrobial activity in the micromolar range and compared with traditional antibiotics, they kill bacteria very rapidly. They act, principally, by the electrostatic attraction to negatively charged bacterial cells and consequently membrane disruption, but their antibacterial activity may also involve interference with metabolic processes or different cytoplasmic targets. AMPs are a group of unique and incredible compounds that may be directed to a therapeutic use either alone or in combination with existing antibiotics.
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Stefania Galdiero, Annarita Falanga, Rita Berisio, Paolo Grieco, Giancarlo Morelli and Massimiliano Galdiero , Antimicrobial Peptides as an Opportunity Against Bacterial Diseases, Current Medicinal Chemistry 2015; 22 (14) . https://dx.doi.org/10.2174/0929867322666150311145632
DOI https://dx.doi.org/10.2174/0929867322666150311145632 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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