Synthesis and Evaluation of Tetrazole-BasedHydrazone Derivatives Bearing a Pyridine Moiety as Antimicrobial Agents

Title:Synthesis and Evaluation of Tetrazole-BasedHydrazone Derivatives Bearing a Pyridine Moiety as Antimicrobial Agents

Volume: 12 Issue: 8

Author(s): Ahmet Ozdemir, Mehlika Dilek Altıntop, Belgin Sever, Zerrin Canturk and Zafer Asım Kaplancıkl

Affiliation:

Keywords: Antimicrobial activity, cytotoxicity, hydrazone, pyridine, tetrazole.

Abstract: 2-[(1-Methyl-1H-tetrazol-5-yl)thio]-N'-[(aryl)methylidene/ethylidene]acetohydrazides were synthesized and investigatedin vitroagainst pathogenic bacteriaand Candidaspecies for their antimicrobial activityusing CLSI broth microdilution method. MTT assay was also carried out to evaluate their cytotoxic effects on NIH/3T3 mouse embryonic fibroblast cell lines.2-((1-Phenyl-1H-tetrazol-5-yl)thio)-N'-(1-(pyridin-3-yl)ethylidene)acetohydrazide can be considered as the most promising antibacterial agent againstEnterococcusfaecalis (ATCC 29212) with a MIC value of 100 µg/mL when compared with chloramphenicol (MIC= 200 µg/mL) and low toxicity against NIH/3T3 cells(IC₅₀>500µg/mL).

Cite this article as:

Ozdemir Ahmet, Dilek Altıntop Mehlika, Sever Belgin, Canturk Zerrin and Asım Kaplancıkl Zafer, Synthesis and Evaluation of Tetrazole-BasedHydrazone Derivatives Bearing a Pyridine Moiety as Antimicrobial Agents, Letters in Drug Design & Discovery 2015; 12 (8) . https://dx.doi.org/10.2174/1570180812666150309235217

DOI https://dx.doi.org/10.2174/1570180812666150309235217	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X