Abstract
A critical review of applications of chlorine kinetic isotope effects in studies of organic reactions mechanisms is presented. Reports from the last five years are considered. During this time chlorine kinetic isotope effects were applied mainly in studies of elimination reactions and nucleophilic substitution reactions. In several cases chemical models were also used as models of the intrinsic kinetic isotope effects in several enzymatic reactions. Both experimental and theoretical approaches have been used.
Keywords: chlorine kinetic isotope effects, elimination reactions, triethylamine(tea)-promoted reactions, nucleophilic substitution
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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