Is Notch Signaling a Specific Target in Hepatocellular Carcinoma?

Title:Is Notch Signaling a Specific Target in Hepatocellular Carcinoma?

Volume: 15 Issue: 7

Author(s): Lichun Sun, Guangchun Sun, Yan Yu and David H. Coy

Affiliation:

Keywords: Hepatocellular carcinoma, Notch signaling, oncogene, therapeutics, tumor suppressor.

Abstract: Hepatocellular carcinoma (HCC) is one of the most malignant cancers, with the second highest cancer death rate world-wide, next to lung cancer. The signaling mechanisms in HCC are currently not clear. Notch signaling, which is highly conserved and plays a critical role in many cancers, was found to be aberrantly upregulated in HCC tissues compared to normal liver tissues. Accumulating evidence supports that Notch signaling plays a significantly important role in HCC carcinogenesis. This review discusses the functions of Notch signaling in HCC and its potential therapeutic applications against this cancer.

Cite this article as:

Sun Lichun, Sun Guangchun, Yu Yan and H. Coy David, Is Notch Signaling a Specific Target in Hepatocellular Carcinoma?, Anti-Cancer Agents in Medicinal Chemistry 2015; 15 (7) . https://dx.doi.org/10.2174/1871520615666150202102809