Homocoupling of Arylboronic Acids Catalyzed by a Simple Hydrophilic Palladium(II) Complex in Aqueous Media

Title:Homocoupling of Arylboronic Acids Catalyzed by a Simple Hydrophilic Palladium(II) Complex in Aqueous Media

Volume: 12 Issue: 3

Author(s): Mengping Guo, Liang Qi, Meiyun Lv, Xiuling Zhou, Hui Liang and Sanbao Chen

Affiliation:

Keywords: Hydrophilic catalyst, homocoupling of arylboronic acids, aqueous media, green chemistry.

Abstract: Homocoupling of arylboronic acids has been successfully carried out by using the inexpensive hydrophilic palladium( II) complex PdCl₂(NH₂CH₂COOH)₂ as catalyst in i-PrOH/H₂O (v/v=1:2) under aerobic atmosphere without elevated heating to give rise to symmetrical biaryls in moderate to good yields. The aqueous media, room temperature reaction and the low amounts of catalyst (0.5 mol%) show a practical and environmentally benign protocol. In addition, enhancement of yield was observed in the presence of 0.5 equiv. p-toluenesulfonyl chloride. Furthermore, the byproducts of this reaction were not observed while biaryl is the only product, which results in much more facile in the separation of the product symmetrical biaryls from arylboronic acids.

Cite this article as:

Guo Mengping, Qi Liang, Lv Meiyun, Zhou Xiuling, Liang Hui and Chen Sanbao, Homocoupling of Arylboronic Acids Catalyzed by a Simple Hydrophilic Palladium(II) Complex in Aqueous Media, Letters in Organic Chemistry 2015; 12 (3) . https://dx.doi.org/10.2174/1570178612666150115001813