通过独特的眼口途径诱发免疫耐受

Title:Immune Tolerance Elicited via Unique Ocular and Oral Routes

Volume: 15 Issue: 1

Author(s): H.M. Ashour

Affiliation:

关键词: 耐受，ACAID，镍，口服耐受，调控T细胞，细胞活素。

摘要: Immune tolerance can be induced by numerous methods. This review article aims to draw lines of similarity and contrast between two unique models of immune tolerance, namely Anterior Chamber Associated Immune Deviation (ACAID) and Nickel-induced oral tolerance. ACAID is an immune tolerance model that leads to the generation of CD4⁺ T regulatory cells and CD8⁺ T regulatory cells in the periphery after the injection of an antigen into the anterior chamber of the eye. Nickel-induced oral tolerance is another immune tolerance model that is induced by the contact allergen Nickel and leads to the generation of Nickel-specific CD4⁺ CD25⁺ T regulatory cells after oral exposure. The goal of comparing different models of immune tolerance is to identify which mechanisms are universal and which mechanisms are model-specific. The knowledge of such mechanisms would allow scientists and clinicians to better intervene in different immune deregulation scenarios.

Cite this article as:

H.M. Ashour , Immune Tolerance Elicited via Unique Ocular and Oral Routes, Current Molecular Medicine 2015; 15 (1) . https://dx.doi.org/10.2174/1566524015666150114114602