一种人体生长激素——透明质酸（作为一种蛋白质的聚合载体）的概述和报告

Title:Hyaluronic Acid as a Protein Polymeric Carrier: An Overview and a Report on Human Growth Hormone

Volume: 16 Issue: 13

Author(s): Anna Mero, Monica Campisi, Michele Caputo, Christian Cuppari, Antonio Rosato, Oddone Schiavon and Gianfranco Pasut

Affiliation:

关键词: 关节炎，生物制药，人生长激素，透明质酸，聚合物共轭，共轭位置选择。

摘要: Hyaluronic acid (HA) is a natural polysaccharide primarily present in the vitreous humor and in cartilages where it plays a key structural role in organizing the cartilage extracellular matrix. HA is used in a wide range of applications including treatment of arthritis (as a viscosupplementation agent for joints) and in a variety of cosmetic injectable products. Its safety profile is thus well established. Thanks to its high biocompatibility and targeting properties, HA has also been investigated for use as a carrier of anticancer drugs and, recently, also of proteins. Its role in the last case is a particularly challenging one as dedicated coupling chemistries are required to preserve the protein’s conformation and activity. This study focuses on the state of the art on protein HAylation. New data from our laboratory on the local delivery of specific biologics to joints will also be outlined.

Cite this article as:

Anna Mero, Monica Campisi, Michele Caputo, Christian Cuppari, Antonio Rosato, Oddone Schiavon and Gianfranco Pasut , Hyaluronic Acid as a Protein Polymeric Carrier: An Overview and a Report on Human Growth Hormone, Current Drug Targets 2015; 16 (13) . https://dx.doi.org/10.2174/1389450116666150107151906