Novel One-Pot Synthesis of 3,4-dihydropyrimidin-2(1H)-ones and 3,4,7,8- tetrahydroquinazoline-2,5-diones Using Pyridinium p-toluenesufonate as Catalyst

Title:Novel One-Pot Synthesis of 3,4-dihydropyrimidin-2(1H)-ones and 3,4,7,8- tetrahydroquinazoline-2,5-diones Using Pyridinium p-toluenesufonate as Catalyst

Volume: 12 Issue: 2

Author(s): Imene Amine Khodja, Raouf Boulcina and Abdelmadjid Debache

Affiliation:

Keywords: 3, 4, 7, 8-tetrahydroquinazoline-2, 5-diones, 3, 4-Dihydropyrimidin-2(1H)-ones, biginelli reaction, pyridinium-ptoluenesufonate.

Abstract: A mild, simple and efficient procedure for the preparation of 3,4-dihydropyrimidin-2(1H)-ones and 3,4,7,8- tetrahydroquinazoline-2,5-diones is described using pyridinium p-toluenesufonate as an efficient catalyst under mild conditions. Simple methodologies, easy work-up procedure, excellent yields and very short reaction times are among the other advantages of this work.

Cite this article as:

Amine Khodja Imene, Boulcina Raouf and Debache Abdelmadjid, Novel One-Pot Synthesis of 3,4-dihydropyrimidin-2(1H)-ones and 3,4,7,8- tetrahydroquinazoline-2,5-diones Using Pyridinium p-toluenesufonate as Catalyst, Letters in Organic Chemistry 2015; 12 (2) . https://dx.doi.org/10.2174/1570178612666141226193727