Encouraging microRNA-based Therapeutic Strategies for Hepatocellular Carcinoma

Title:Encouraging microRNA-based Therapeutic Strategies for Hepatocellular Carcinoma

Volume: 15 Issue: 4

Author(s): Min Yao, Li Wang, Liwei Qiu, Qi Qian and Dengfu Yao

Affiliation:

Keywords: Hepatocellular carcinoma, microRNA, molecular target, therapy.

Abstract: Hepatocellular carcinoma (HCC) is one of the most common and rapidly fatal malignancies worldwide with poor prognosis. Most of the HCC patients died quickly because of the rapid tumor progression with no effective therapy except for liver resection or transplantation. Recently, microRNAs (miRNAs) have emerged as key factors involved in a series of biological processes ranging from embryogenesis to programmed cell death with aberrant expression profiles, potentially attractive diagnosis, prognosis or therapeutic applications for related-diseases. Accumulating evidences have indicated the roles of miRNAs as tumor suppressor in hepatocyte malignant transformation including development, differentiation, proliferation and tumorigenesis. This article reviews that the recent progress underlies the development of novel miRNA-based HCC therapeutic strategies in the coming future.

Cite this article as:

Yao Min, Wang Li, Qiu Liwei, Qian Qi and Yao Dengfu, Encouraging microRNA-based Therapeutic Strategies for Hepatocellular Carcinoma, Anti-Cancer Agents in Medicinal Chemistry 2015; 15 (4) . https://dx.doi.org/10.2174/1871520615666141216150135