Chemoenzymatic Synthesis of Carbohydrates as Antidiabetic and Anticancer Drugs

Title:Chemoenzymatic Synthesis of Carbohydrates as Antidiabetic and Anticancer Drugs

Volume: 14 Issue: 23

Author(s): Andres R. Alcantara, Vittorio Pace, Pilar Hoyos, Manuel Sandoval, Wolfgang Holzer and Maria J. Hernaiz

Affiliation:

Keywords: Carbohydrates, Glycomimetic, Biocatalysis, Antidiabetic drugs, Anticancer drugs.

Abstract: Different chemoenzymatic strategies for the preparation of carbohydrates and analogues possessing antidiabetic or anticancer activity are summarized. In this sense, some examples illustrating the use of enzymes such as aldolases, lipases or glycosidases (in some cases improved by genetic engineering techniques) are presented, showing the advantages of the implementation of chemoenzymatic protocols, which combine the flexibility of chemical synthesis with the efficiency, selectivity and sustainability of biotransformations to obtain diverse complex carbohydrates, glycoconjugates and glycomimetics.

Cite this article as:

Alcantara R. Andres, Pace Vittorio, Hoyos Pilar, Sandoval Manuel, Holzer Wolfgang and Hernaiz J. Maria, Chemoenzymatic Synthesis of Carbohydrates as Antidiabetic and Anticancer Drugs, Current Topics in Medicinal Chemistry 2014; 14 (23) . https://dx.doi.org/10.2174/1568026614666141215151056