Discovery Strategies in a BioPharmaceutical Startup: Maximising your Chances of Success Using Computational Filters

A.      Jennings; M.      Tennant

doi:10.2174/1381612053382151

Abstract

Small research-based pharmaceutical start-ups often lack the budget and do not have the infrastructure available to apply all possible techniques for compound selection. This review details our use of a range of techniques such as high-throughput docking and similarity searching to maximize the success rate when attempting to identify pharmaceutically relevant ligands in a resource-constrained environment.

Keywords: docking methods, murein synthetic pathway, enzymes, murb assay, diversity metrics, pharmacophore

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Current Pharmaceutical Design

Title: Discovery Strategies in a BioPharmaceutical Startup: Maximising your Chances of Success Using Computational Filters

Volume: 11 Issue: 3

Author(s): A. Jennings and M. Tennant

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Keywords: docking methods, murein synthetic pathway, enzymes, murb assay, diversity metrics, pharmacophore

Abstract: Small research-based pharmaceutical start-ups often lack the budget and do not have the infrastructure available to apply all possible techniques for compound selection. This review details our use of a range of techniques such as high-throughput docking and similarity searching to maximize the success rate when attempting to identify pharmaceutically relevant ligands in a resource-constrained environment.

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Jennings A. and Tennant M., Discovery Strategies in a BioPharmaceutical Startup: Maximising your Chances of Success Using Computational Filters, Current Pharmaceutical Design 2005; 11 (3) . https://dx.doi.org/10.2174/1381612053382151