Abstract
Propargylic alcohols with aryl/heteroaryl groups at C1 position have received significant attention as alkylating agents in direct nucleophilic SN1-type reactions towards the formation of new C-C, C-O, C-N and C-S bonds. Taking advantage of the versatile alkyne functionality, the obtained propargylated derivatives have been transformed into various types of heterocycles as well as carbocycles. This review demonstrates the efficacy and versatility of 1-aryl propargylic alcohols in the synthesis of 5- and 6-membered heterocycles and carbocycles.
Keywords: Carbocycles, heterocycles, propargylic alcohols, SN1-substitution.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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