Superior Cell Adhesion and Antithrombogenicity Supported by N⁺-bombarded Carbon Nanotubes

Title:Superior Cell Adhesion and Antithrombogenicity Supported by N⁺-bombarded Carbon Nanotubes

Volume: 11 Issue: 1

Author(s): M.L. Zhao, X.Q. Liu, Y. Cao, D.J. Li and H.Q. Gu

Affiliation:

Keywords: antithrombogenicity, cell adhesion, ion beam assisted deposition, Multi-walled carbon nanotubes, N⁺-bombarded multi-walled carbon nanotubes, .

Abstract: Super hydrophilic multi-walled carbon nanotubes (MWCNTs) were bombarded by N ions through ion beam assisted deposition. MWCNTs were synthesized via chemical vapor deposition. Biological tests in vitro were performed on raw MWCNTs and N⁺-bombarded MWCNTs. Cellular adhesion was investigated both using human endothelial cells and mouse fibroblast cells. Results showed that N⁺-bombarded MWCNTs stimulated cell growth and proliferation, revealing superior cell adhesion. Antithrombogenicity of raw and N⁺-bombarded MWCNTs was evaluated by platelet conglutination, hemolysis and kinetic-clotting assays. Compared with raw MWCNTs, N⁺-bombarded MWCNTs displayed better morphology of platelets and red blood cells, longer kinetic blood-clotting time, which increased their thromboresistance, further antithrombogenicity.

Cite this article as:

Zhao M.L., Liu X.Q., Cao Y., Li D.J. and Gu H.Q., Superior Cell Adhesion and Antithrombogenicity Supported by N⁺-bombarded Carbon Nanotubes, Current Nanoscience 2015; 11 (1) . https://dx.doi.org/10.2174/1573413710666141021235558