抗糖尿病药物二甲双胍：用于癌症治疗的挑战和前景

Title:Anti-diabetic Drug Metformin: Challenges and Perspectives for Cancer Therapy

Volume: 14 Issue: 8

Author(s): Kaniyampadi Sreenivasan Snima, Prathesha Pillai, Aleena Mary Cherian, Shantikumar V. Nair and Vinoth-Kumar Lakshmanan

Affiliation:

关键词: 乳腺癌，子宫内膜癌，二甲双胍，纳米技术，前列腺癌，卵巢癌，胰腺癌，途径

摘要: Metformin, a biguanide, is a commonly administered drug for the management of type 2 diabetes mellitus. The drug received tremendous recognition, when retrospective studies proved metformin-associated reduction in cancer risk. Metformin has potential anticancer effects and an ability to suppress tumor growth both in vitro and in vivo. Activation of LKB1/AMPK pathway and cancer stem cell destruction along with cell cycle arrest and apoptosis induction are the proposed mechanisms of anticancer potential of metformin. Nanotechnology approaches have also been adopted for metformin delivery to cancer cells. This review directs on the application of metformin for the therapy of various cancers and also the different pathways responsible for the metformin derived anticancer effect. It also focuses on the pharmacological applications of metformin and the nanotechnology approaches for metformin delivery.

Cite this article as:

Kaniyampadi Sreenivasan Snima, Prathesha Pillai, Aleena Mary Cherian, Shantikumar V. Nair and Lakshmanan Vinoth-Kumar, Anti-diabetic Drug Metformin: Challenges and Perspectives for Cancer Therapy, Current Cancer Drug Targets 2014; 14 (8) . https://dx.doi.org/10.2174/1568009614666141020105502