A Review on Modelling Methods, Pathway Simulation Software and Recent Development on Differential Evolution Algorithms for Metabolic Pathways in Systems Biology

Title:A Review on Modelling Methods, Pathway Simulation Software and Recent Development on Differential Evolution Algorithms for Metabolic Pathways in Systems Biology

Volume: 9 Issue: 5

Author(s): Chuii Khim Chong, Mohd Saberi Mohamad, Safaai Deris, Mohd Shahir Shamsir, Yee Wen Choon and Lian En Chai

Affiliation:

Keywords: Differential evolution, modelling, system biology.

Abstract: The process of analysing metabolic pathways mathematically in systems biology requires accurate parameters which represent the simulated in-vivo processes. Differential Evolution algorithm (DE) has been provenable to outperform other estimation algorithms, and has been used to achieve an accurate estimation of the required parameters. The total number of DE-variants has increased recently, which makes researchers face difficulties in obtaining complete overview of current DE-variants. To provide a holistic view to the area of mathematical modelling in System Biology, through this paper, we present an overview of modelling methods, parameter estimation by utilizing DE-variants to analyse metabolic pathways, and exiting pathway simulation software.

Cite this article as:

Chong Khim Chuii, Mohamad Saberi Mohd, Deris Safaai, Shamsir Shahir Mohd, Choon Wen Yee and Chai En Lian, A Review on Modelling Methods, Pathway Simulation Software and Recent Development on Differential Evolution Algorithms for Metabolic Pathways in Systems Biology, Current Bioinformatics 2014; 9 (5) . https://dx.doi.org/10.2174/157489360905141014154242