Dendritic Cells: A Double-Edge Sword in Atherosclerotic Inflammation

Title:Dendritic Cells: A Double-Edge Sword in Atherosclerotic Inflammation

Volume: 21 Issue: 9

Author(s): Dimitry A. Chistiakov, Igor A. Sobenin, Alexander N. Orekhov and Yuri V. Bobryshev

Affiliation:

Keywords: Atherosclerosis, arteriosclerosis, arteries, inflammation, dendritic cells, plasmacytoid dendritic cells.

Abstract: Functional heterogeneity of dendritic cells (DCs) observed in atherosclerosis suggest for their complex and multifaced role in the pathogenesis of atherosclerotic disease. A delicate balance between anti-inflammatory and pro-inflammatory mechanisms drives atherogenesis, and local microenvironment triggers the actual involvement of DCs in atherosclerosis-associated inflammation. Responding to microenvironment stimuli, DCs contribute to atherogenesis in both ways being involved in supporting proatherogenic vascular inflammation and by suppressing inflammatory responses via induction of self-tolerogenic properties and regulatory T cells (Tregs). The local microenvironment and extrinsic stimuli influence DC phenotype and hence could control the phenotypic switch toward inflammation or tolerance.

Cite this article as:

Chistiakov A. Dimitry, Sobenin A. Igor, Orekhov N. Alexander and Bobryshev V. Yuri, Dendritic Cells: A Double-Edge Sword in Atherosclerotic Inflammation, Current Pharmaceutical Design 2015; 21 (9) . https://dx.doi.org/10.2174/1381612820666141013162528