摘要
糖尿病是在中老年人群中阿尔茨海默病(AD)的发展众所周知的风险因素。糖尿病和AD之间的分子联系仍然没有完全了解。最近的证据表明,在糖尿病上观察到血小板的活化可能有助于AD的发展。本综述概括了糖尿病和AD的病理生理学中的常见分子机制,并为预防发病或延缓这种疾病的发展提出新的治疗目标。
关键词: 阿尔茨海默病,糖尿病,血小板,血管性痴呆
Current Alzheimer Research
Title:Platelets as Potential Link Between Diabetes and Alzheimer's Disease
Volume: 11 Issue: 9
Author(s): Voahanginirina Randriamboavonjy, Kateryna Sopova, Konstantinos Stellos and Christoph Laske
Affiliation:
关键词: 阿尔茨海默病,糖尿病,血小板,血管性痴呆
摘要: Diabetes is a well-known risk factor for Alzheimer`s disease (AD) development in the elderly. The molecular link between diabetes and AD is still not completely understood. Recent evidence suggests that platelet activation observed in diabetes may contribute to AD development. The present review summarizes the common molecular mechanisms involved in the pathophysiology of diabetes and AD and suggests novel therapeutic targets for prevention of the onset or slowing the progression of this disease.
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Cite this article as:
Randriamboavonjy Voahanginirina, Sopova Kateryna, Stellos Konstantinos and Laske Christoph, Platelets as Potential Link Between Diabetes and Alzheimer's Disease, Current Alzheimer Research 2014; 11 (9) . https://dx.doi.org/10.2174/156720501109141013115258
DOI https://dx.doi.org/10.2174/156720501109141013115258 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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