Disruption of Metabolic Pathways - Perspectives for the Treatment of Cancer

Title: Disruption of Metabolic Pathways - Perspectives for the Treatment of Cancer

Volume: 6 Issue: 1

Author(s): Eliana P. Araujo, Jose B. Carvalheira and Licio A. Velloso

Affiliation:

Keywords: protein kinase B, protein remodeling, Akt Activation, phosphotyrosine binding (PTB), CCI-779, Antisense oligonucleotides

Abstract: Several growth-promoting signaling pathways have tight molecular connections with metabolicrelated signal transduction systems. By controlling these pathways, cancer cells gain autonomy over energyacquiring systems and, thus, expand their potential for proliferation. Here, we discuss the use of drug and antisense oligonucleotide approaches to inhibit metabolic pathways in cancer cells and their potential use in the therapeutics of cancer.

Cite this article as:

Araujo P. Eliana, Carvalheira B. Jose and Velloso A. Licio, Disruption of Metabolic Pathways - Perspectives for the Treatment of Cancer, Current Cancer Drug Targets 2006; 6 (1) . https://dx.doi.org/10.2174/156800906775471734